The Main Street–Frye Street Historic District is a historic district comprising houses on Frye Street and parts of College Street and Main Street in Lewiston, Maine. This area was part of the most fashionable residential district of the city in the second half of the 19th century, and was home to many of the city's elite. Its architectural styles are diverse, with a significant number of homes designed by local architect George M. Coombs. The district was added to the National Register of Historic Places in 2009.